A majority of respondents (45%) did not perceive any challenges with adopting PRS in their organization, indicating that effective governance and methodology to gather the necessary information to evaluate a product portfolio are well understood and managed. However, 27% of the respondents highlighted the challenge of aligning LOC and different groups to the data governance process, possibly due to the challenge of accessing information. 18% of the respondents reported that gathering data to assess risk on a periodic basis takes time, which complements the prior response because organizations may have data accessibility issues. Only 9% of the respondents reported that this is a new area they have not yet initiated. Although a significant portion of organizations are prepared for PTRS, there are still notable challenges. Organizations should establish a governance process for communicating the approach and process to the various stakeholders that should be followed and subsequently clarify data that will contribute to the assessment, including regulatory and competitive intelligence, purchased data on trends and insights, as well as function-specific data from manufacturing, epidemiology, clinical, safety, and other functions.