Bedminster/Princeton, NJ, July 23, 2020: Alfasigma USA, Inc. today announced a strategic deal with Indegene, Inc., a global life sciences and healthcare solutions provider, to co-promote its Irritable Bowel Syndrome with Constipation (IBS-C) drug, ZELNORM® (tegaserod), to prescribers across the United States. ZELNORM® was approved for reintroduction by the FDA for the treatment of adult women less than 65 years of age with IBS-C in March 2019. Alfasigma acquired the brand in July 2019 from Sloan Pharma S.à r.l, a subsidiary of US WorldMeds Holdings, LLC.
According to William Griffing, Vice President, Head of Marketing at Alfasigma USA, “ZELNORM® is a unique treatment for IBS-C with demonstrated efficacy and safety. Our partnership with Indegene will complement our ongoing commercial efforts to make ZELNORM® a viable therapeutic option for women less than 65 years of age who suffer from IBS-C. We will continue to invest in our current field forcewhile at the same time expanding our footprint in the US by bringing Indegene on board.”
IBS is prevalent in 7%-21% of adults worldwide and in 5%-9% of US adults. Its prevalence has increased over the past several decades and is particularly high in adult female patients less than 50 years of age.1-5 IBS is associated with substantially impaired quality of life, including effects on lifestyle, daily activities, and sleep, as well as work absenteeism.
ZELNORM® is the only selective serotonin-4 (5-HT4) receptor agonist approved to treat IBS-C. It provides a unique treatment by targeting the 5-HT4 receptor at multiple neurons (sensory motor, secretory motor) and smooth muscle cells in the gastrointestinal tract to induce contraction and relaxation and decrease pain signaling.
According to Gaurav Kapoor, EVP, Global Product Commercialization, Indegene, “There is substantial evidence in the growth of digital channel adoption by physicians now more so with the drop in face to face interactions. AI-enabled physician targeting through Indegene’s proprietary APEX platform is a sure-fire way to engage the prescriber and patient community in the new normal. We are upbeat about taking ZELNORM® to a new level of awareness amongst prescribers using Indegene APEX. Backed with demonstrated outcomes, ZELNORM® prescriptions will definitely see an uptick in the coming months.”
Indegene’s APEX platform is a comprehensive suite of solutions including Creative Services; Omnichannel Marketing; Digital-Enabled Sales; Global Regulatory; Safety & Compliance; Medical Affairs; Training & Communication; Pricing; Market Access; Payer & PBM Management; and Logistics & Distribution, thus providing drug makers a ready-built, fully integrated and tested commercial infrastructure.
For more information, please see the Medication Guide and full Prescribing Information for ZELNORM® at www.ZELNORMus.com.
1) Hungin AP, et al. Aliment Pharmacol Ther. 2003;17(5):643-650.
2) Halder SL, et al. Gastroenterology. 2007;133(3):799-807.
3) Ford AC, et al. Am J Gastroenterol. 2008;103(5):1229-1239.
4) Lovell RM, et al. Clin Gastroenterol Hepatol. 2012;10(7):712-721.e4.
5) Mearin F, et al. Gastroenterology. 2016. doi:10.1053/j.gastro.2016.02.03.
About Alfasigma USA, Inc.:
Alfasigma USA, Inc. is the American affiliate of Alfasigma, a leading Italian pharmaceutical company. Alfasigma is present in more than 90 countries, with a workforce of around 3000 people and 5 manufacturing plants. Alfasigma USA, Inc. distributes a portfolio of prescription nutritional products to help individuals who are suffering from GI disorders (VSL#3®), major depressive disorder (DEPLIN®), diabetic peripheral neuropathy (METANX®), and mild cognitive impairment (CerefolinNAC®). With the acquisition of ZELNORM®, Alfasigma USA is building on their commitment to making “Pharmaceuticals with Passion” in the US. For more information, please visit www.alfasigmausa.com or email firstname.lastname@example.org.
We are a digital-first, life sciences commercialization company. We help biopharmaceutical, emerging biotech and medical device companies develop products, get them to the market, and grow their impact through the life cycle in a more effective, efficient, and modern way. We bring together healthcare domain expertise, fit-for-purpose technology, and an agile operating model to provide a diverse range of solutions. These aim to deliver, amongst other outcomes, a personalized, scalable and omnichannel experience for patients and physicians. It’s what drives our team and our purpose to enable healthcare organizations to be future ready. To learn more, please visit www.indegene.com
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